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Surgery Patients On Beta-Blocker Therapy Prior To Admission Who Received ABeta-Blocker During The Perioperative Period

In patients at risk of cardiovascular complications in a variety of medical conditions, beta-blockers have shown to reduce that risk. Studies show that patients with a history of myocardial infarction who have had beta-blocker therapy initiated and continued, have a 20 to 30% reduction in subsequent coronary events, cardiovascular mortality, and all-cause mortality (Yusuf, 1985). In a meta analysis by McGory? et al (2005), long-term cardiac mortality and myocardial ischemia were reduced significantly by perioperative beta blockade. Patients maintained on beta-blockers, without complications that might warrant discontinuation, are good candidates for continuation of beta-blockers through the perioperative period.
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References

  • Manual of Medical Therapeutics. Department of Medicine Washington University, School of Medicine, St. Louis, MO, GA Ewald and CR McKenzie? editors. 28th Edition, 1995. PMID: 0000000.
  • Belzberg H, Rivkind AI. Preoperative cardiac preparation. Chest. 1999;115:82S-95S. PMID: 10331339.
  • Poldermans D, Boersma E, Bax JJ, et al, for the DECREASE Study Group. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. N Engl J Med. 1999;24:1789-1794. PMID: 10588963.
  • Shammash JB, Trost JC, Gold JM, et al. Perioperative beta-blocker withdrawal and mortality in vascular surgical patients. Am Heart J. 2001;141:148-153. PMID: 11136500.
  • Boersma E, Poldermans D, Bax JJ, et al, for the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) Study Group. Predictors of cardiac events after major vascular surgery: role of clinical characteristics, dobutamine echocardiography. PMID:11308400.
  • Pasternack PF, Imparato AM, Baumann FG, et al. The hemodynamics of beta-blockade in patients undergoing abdominal aortic aneurysm repair. Circulation. 1987;76(suppl 3, pt 2):III-1-7. PMID:3621532.
  • Yaeger RA, Moneta GL, Edwards JM, et al. Reducing perioperative myocardial infarction following vascular surgery. The potential role of beta-blockade. Archives of Surgery 1995;130(8):869. http://archsurg.ama-assn.org/cgi/content/abstract/130/8/869. (Last accessed 11/16/07) PMID:7632148.
  • Yusuf S, Peto R, Lewis J, Collins R, et al. Beta Blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; 27: 335-371. PMID: 2858114.
  • McGory? ML, Maggard MA, Ko CY. A meta-analysis of perioperative beta blockade: What is the actual risk reduction? Surgery. 2005 Aug;138(2):171-179. PMID: 16153424.
  • Fleisher LA, Beckman JA, Brown KA, Calkins H, et al. ACC/AHA 2006 Guideline update on perioperative cardiovascular evaluation for noncardiac surgery: Focused update on perioperative beta-blocker therapy. Am Coll J Cardiol, Vol 47.
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r3 - 20 Nov 2007 - 10:37:32 - BretteTschurtz
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